2 . 0 Review of Literature

Suppositories which are designed to melt at the physiological temperature compare to oral administration the rectal or vaginal drug delivery has gain importance therapeutically by avoiding the first pass metabolism. Suppositories are semisolid dosage form; they induce local effect after insertion into the body cavities. Suppositories offers many advantages a) the portal circulation is bypassed prevent first pass metabolism b) drug irritating in gastric mucosa can be given in this manner c) the influence of gastric pH and enzymatic juices can be avoided d) it can administered to patients who cannot or will not swallow e) absorption of rectum will be more rapid and more regular than from stomach or intestine f) duration of action can be prolonged, with few of disadvantages a) patient acceptability b) limited knowledge mechanism.